I have to back up the comments about the Dvorak keyboard. I’m disappointed only two people have made it so far.
It’s really hard at first, just like learning to type again, but very much worth it.
One problem: it makes using the mouse even harder. Keys under Dvorak are positioned so that you use a finger on your left hand then a finger on your right, alternating, as much as possible. If you’re forced to type with one hand while keeping the mouse in the other (pretty rare, but it happens when I play online crosswords, which are all terribly designed) your left hand jumps from one side of the keyboard to the other all the time. A real pain. Also happens if I’ve got a cup in my hand.
Apparently there are Dvorak-type layouts optimised for either left- or right-hand usage also, which would be great for amputees.
One final problem: you’ll eventually lose your qwerty skills which is inconvenient when you’re forced to use someone else’s machine. I could actually quite comfortably use both for quite a few years, but over the last couple I’ve finally lost my qwerty skills.